Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-UpJohn Wiley & Sons, 23. 2. 2011. - 376 страница There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame. |
Садржај
Analytical Methods | 34 |
Lexapro Escitalopram Oxalate | 37 |
References | 78 |
Effexor XR Venlafaxine Hydrochloride | 70 |
Dimethylethanethioamide 16 | 70 |
Seroquel | 94 |
Hemifumarate | 59 |
Singulair Montelukast Sodium | 77 |
References | 81 |
Prevacid Lansoprazole | 54 |
Advair Diskus Salmeterol Xinafoate | 51 |
References | 45 |
Lipitor Atorvastatin Calcium | 53 |
Identifying Process Impurities and Evaluating Drug Product | 129 |
References | 129 |
Друга издања - Прикажи све
Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to ... Peter J. Harrington Приказ није доступан - 2011 |
Чести термини и фразе
1.0 equivalent acetic acid acetone added to pH aged at 25°C Aldrich ammonium hydroxide aqueous layer bromide catalog price catalyst citalopram 39 concentrated at reduced cooled to 25°C cyclization dichloromethane diluted diol distilled at reduced dried and concentrated dried to afford ester ethyl acetate extracted with ethyl extracted with toluene formaldehyde formic acid free base Grignard reagent hemifumarate hydride hydrochloric acid isolated isopropanol ketone lansoprazole lansoprazole sulfide layer is washed layers are separated liquors are concentrated methanesulfonate methanol mixture is aged mixture is cooled montelukast nitrile organic layer oxidation palladium on carbon Patent phosphorus oxychloride pioglitazone polymorph pressure to afford produced pure by HPLC quetiapine reaction reduced pressure resulting suspension RS)-diol salmeterol salt Scheme sodium hydroxide solid is washed solvent suspension is aged suspension is cooled suspension is filtered THF is added thionyl chloride toluene triethylamine unspecified temperature washed with water Williamson ether synthesis workup yield