Molecular Photofitting: Predicting Ancestry and Phenotype Using DNA

Предња корица
Elsevier, 19. 7. 2010. - 712 страница

In the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects.

Molecular Photofitting provides an accessible roadmap for both the forensic scientist hoping to make use of the new tests becoming available, and for the human genetic researcher working to discover the panels of markers that comprise these tests. By implementing population structure as a practical forensics and clinical genomics tool, Molecular Photofitting serves to redefine the way science and history look at ancestry and genetics, and shows how these tools can be used to maximize the efficacy of our criminal justice system.

  • Explains how physical descriptions of individuals can be generated using only their DNA
  • Contains case studies that show how this new forensic technology is used in practical application
  • Includes over 100 diagrams, tables, and photos to illustrate and outline complex concepts
 

Садржај

Forensic DNA Analysis From Modest Beginnings to Molecular Photofitting Genics Genetics Genomics and the Pertinent Population Genetics Principles
1
Ancestry and Admixture
35
Biogeographical Ancestry Admixture EstimationTheoretical Considerations
57
Biogeographical Ancestry Admixture EstimationPracticality and Application
145
Characterizing Admixture Panels
203
Apportionment of Autosomal Diversity With Continental Markers
297
Apportionment of Autosomal Diversity with Subcontinental Markers
361
Indirect Methods for Phenotype Inference
429
Direct Method of Phenotype Inference
497
The First Case Studies of Molecular Photofitting
599
The Politics and Ethics of Genetic Ancestry Testing
609
Bibliography
661
Index
677
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