Calcium phosphate Ceramics - Bioresorbable Polymer Composite Biomaterials: from synthesis to applications : (1999-2007)Dragan P. Uskoković, Nenad L. Ignjatović Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, 1. 10. 2007. - 424 страница In the past several years, the accent of a number of scientific researches in the countries of the European Union, USA and Japan was focused on the field of biomaterials. Having the direct influence on the quality and longevity of human life, these researches receive significant funding. The bone tissue is an especially interesting subject of scientific research, as much for the frequent osteoporosis as for the formative nature of organism. Natural bone is mostly composed of nanostructural calcium phosphate (hydroxyapatite). Whether bone trauma was caused artificially or through illness, the number of reconstructions increases every year worldwide and thus the monetary investment into this field. Until now, numerous kinds of biomaterials were used for this purpose. Development of equipment and progress in characterization techniques and devices enabled an exponential development of new and advanced biomaterials’ synthesis. Many qualitative and quantitative content concepts and the organization of biomaterials on all structural levels were taken from nature. Biomaterials for the reconstruction of bone tissue, very similar to human tissue, in the form of composite blocks, injectable cements, nano-fillers, etc., were produced this way. Synthesis of calcium phosphate and hydroxyapatite, as well as the composite for the reconstruction of bone tissue, has been a significant research field of a section of Advanced Materials and Processes Department of the Institute of Technical Sciences of the Serbian Academy of Sciences and Arts (ITS SASA) from Belgrade for a number of years. Apart from a number of published scientific papers in leading international journals, lectures presented at the leading universities worldwide, several PhD dissertations defended at various faculties in the land, and several domestic patents, researchers have established the basis of the technological procedure and the production of small series of various products developed in their laboratory. These researches have very wide aspect of significance – from fundamental, scientific to specifically applicative. It can be said that these researches include everything from synthesis, processing, characterization to their application. This book contains 44 papers published in SCI journals since 1999 until May 2007. It is divided into five sections and each assembles the most important results in the specific area: I Synthesis and Processing, II Synthesis, Properties and Characterization of Biomaterials, III Mechanical Properties and Modelling of Biomaterials, IV Biological Evaluation of Biomaterials, V Behaviour of Biomaterials under Radiation Field. |
Садржај
Synthesis and properties of hydroxyapatitepolyllactide composite biomaterials | 3 |
Microstructural characteristics of calcium hydroxyapatitepolyllactide based composites | 13 |
Hydroxyapatitepolyllactide collagen biocomposite with polyllactide of different molecular weights | 21 |
Synthesis and characterization of hydroxyapatitecollagen biocomposite materials | 29 |
Injectable polydimethylsiloxanehydroxyapatite composite cement | 35 |
Preparation and properties of polymeric and composite bioresorbable barrier membranes | 45 |
Influence of urea as a homogeneous precipitation agent on sonochemical hydroxyapatite synthesis | 53 |
Mechanochemical synthesis of nanostructured fluorapatitefluorhydroxyapatite and carbonated fluorapatitefluorhydroxyapatite | 61 |
The influence of hydroxyapatite modification on the crosslinking of polydimethylsiloxaneHAp composites | 217 |
Section III Mechanical properties and modelling of biomaterials | 227 |
Stress analysis in hydroxyapatitepolyllactide composite biomaterials | 229 |
Finite element modeling of mechanical properties of particulate composite biomaterials | 239 |
Predictive modeling of the mechanical properties of particulate hydroxyapatite reinforced polymer composites | 245 |
Processing and mechanical properties of biphasic calciumphosphatepolyllactide composite biomaterials | 257 |
Estimation of elastic properties of a particulate polymer composite using a facecentered cubic FE model | 263 |
Nanoindentation of in situ polymers in hydroxyapatitepolyllactide biocomposites | 271 |
Calcium hydroxyapatite thin films on titanium substrates prepared by ultrasonic spray pyrolysis | 77 |
Synthesis of nanostructured carbonated calcium hydroxyapatite by ultrasonic spray pyrolysis | 89 |
Surface Properties of HAp Particles obtained by hydrothermal decomposition of urea and calciumEDTA chelates | 97 |
Influence of synthesis parameters on the particle sizes of nanostructured calciumhydroxyapatite | 103 |
Synthesis and characterization of biphasic calcium phosphatepolyDLlactidecoglycolide biocomposite | 109 |
Stereological analysis of the polyDL lactidecoglycolide submicron sphere prepared by solventnonsolvent chemical methods and centrifugal processing | 117 |
The effect of processing parameters on characteristics of polyllactide microspheres | 125 |
Section IISynthesis properties and charac terization of biomaterials | 133 |
Synthesis and application of hydroxyapatitepolylactide composite biomaterial | 135 |
The designing of properties of hydroxyapatitepolyllactide composite biomaterials by hot pressing | 143 |
Microstructure and mechanical properties of hotpressed hydroxyapatitepolyllactide biomaterials | 151 |
Structure and characteristics of the hot pressed hydroxyapatitepolyllactide composite | 157 |
Evaluation of hotpressed hydroxyapatitepolyllactide composite biomaterial characteristics | 171 |
Biphasic calcium phosphate coated with polydllactidecoglycolide biomaterialas a bone substitute | 187 |
The formation and characterization of nanocrystalline phases by mechanical milling of biphasic calcium phosphatepolyllactide biocomposite | 195 |
XRD analysis of calcium phosphate and biocomposite calcium phosphatebioresorbable polymer | 205 |
Influence of the HAp ratio on the thermodynamic and kinetic parameters of PDMS HAp composite crosslink ing | 211 |
Micromechanical properties of a hydroxyapatitepolyllactide biocomposite using nanoindentation and modulus mapping | 279 |
Section IV Biological evaluation of biomaterials | 289 |
A study of HApPLLA composite as a substitute for bone powder using FTIR spectroscopy | 291 |
Analysis of in vivo substitution of bone tissue by HApPLLA composite biomaterial with PLLA of different molecular weights using FTIR spectroscopy | 299 |
Molecular spectroscopy analysis of the substitution of bone tissue by HApPLLA composite biomaterial | 309 |
Biological evaluation of hydroxyapatitepolyLlactide HApPLLA composite biomaterials with polyLlactide of different molecular weights intraperiton... | 321 |
Repair of bone tissue affected by osteoporosis with hydroxyapatitepolyLlactide HApPLLAwith and without blood plasma | 331 |
New biocomposite biphasic calcium phosphatepolyDLla ctidecoglycolidebiostimulative agent filler for reconstruction of bone tissue changed by oste... | 339 |
Biphasic calcium phosphatepolyDLlactidecoglycolide biocomposite as filler and blocks for reparation of bone tissue | 349 |
Cytotoxicity and fibroblast properties during in vitro test of biphasic calcium phosphatepolyDLla ctidecoglycolide biocomposites and different phosp... | 357 |
Substitution of osteoporotic alveolar bone by biphasic calcium phosphatepolyDLlactidecoglycolide biomaterials | 369 |
Section V Behaviour of biomaterials under radiation field | 379 |
Gamma irradiation processing of hydroxyapatitepolyLlactide composite biomaterial | 381 |
Radiationinduced degradation of hydroxyapatitepoly Llactide composite biomaterial | 389 |
The influence of gamma radiation on the glass transition of hydroxyapatitepoly llactide composite | 399 |
CI P Katalogizacija u publikaciji | 406 |
Back cover | 407 |
Чести термини и фразе
absorption bands alveolar bone analysis apatite BCP/PLLA Belgrade Bioceramics biocompatibility bioma Biomed Bioresorbable bioresorption biphasic calcium blocks bone tissue calcium hydroxyapatite calcium phosphate ceramic characteristics cm-¹ cm¹ collagen component compressive strength cross-linking crystallinity curves decrease degradation density diameter diffraction DLPLG dose Dragan elastic enthalpy experimental fibroblast FT-IR ft-ir spectroscopy g/mole hAp and PLLA hAp granules hAp particles HAp/PLLA biocomposite HAp/PLLA composite biomaterial hot pressing hydroxyapatite/poly-l-lactide Ignjatović implantation increase indenter irradiation Knez mihailova L-lactide mass fraction Materials Science matrix mechanical properties melting microstructure modulus molecular weight Nenad obtained osteoblasts osteoporosis parameters PDmS PDMS/HAP peak Plavsic PLLA PLLA composite poly-l-lactide polylactide polymer porosity powder ratio samples scanning electron microscopy Serbia Serbian Academy Shikinami shown in Fig spectra spectrum stress structure surface synthesis temperature thermal tion Uskoković values vibrations vivo volume fraction Von mises stress X-ray