Health Effects of Halogenated Aromatic HydrocarbonsWilliam Jamieson Nicholson, John Arthur Moore, New York Academy of Sciences New York Academy of Sciences, 1979 - 730 страница |
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Страница 134
... metabolites should show evidence of the " NIH - shift " as predicted by Daly and Jerina.25,26 The shift of both chlorine and bromine atoms were observed in the studies of halogenated benzene metabolism by Safe's group . 23,24 This group ...
... metabolites should show evidence of the " NIH - shift " as predicted by Daly and Jerina.25,26 The shift of both chlorine and bromine atoms were observed in the studies of halogenated benzene metabolism by Safe's group . 23,24 This group ...
Страница 135
... metabolites of this pentachlorobiphenyl are 3 - hydroxy and 3,4 - dihydroxy 2,5,2 ′ , 4 ′ , 5 ′ - pentachlorobiphenyl.34 However , the addi- tion of a single chlorine atom to the 4 ' position of the pentachlorobiphenyl to form 2,4,5,2 ...
... metabolites of this pentachlorobiphenyl are 3 - hydroxy and 3,4 - dihydroxy 2,5,2 ′ , 4 ′ , 5 ′ - pentachlorobiphenyl.34 However , the addi- tion of a single chlorine atom to the 4 ' position of the pentachlorobiphenyl to form 2,4,5,2 ...
Страница 250
... metabolites . It was felt that working in vitro would help to eliminate the uncertainty that often arises in establishing the origin and mode of production of metabolites because of possible effects of digestive tract physiology and ...
... metabolites . It was felt that working in vitro would help to eliminate the uncertainty that often arises in establishing the origin and mode of production of metabolites because of possible effects of digestive tract physiology and ...
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Production Chemistry and Distribution | 1 |
Sample Handling Extraction | 19 |
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2,3,7,8-tetrachlorodibenzo-p-dioxin abnormalities adipose AHH activity analysis animals antibody antigen Aroclor aromatic assay Biochem blood body weight cells Chem chemicals chloracne chlordane chlordecone chlorinated compounds Contam contaminated correlation cultures decreased detection dibenzofurans dioxin DMBA dose DOTC dredging effects ELISA Environ environmental enzyme excretion exposed farm residents females FIGURE fish function halogenated Health Perspect hepatic hexachlorophene Hudson River hydrocarbons immune increased indicated induced injected isomers J. A. MOORE Kepone laboratory lesions lipid liver lymphocytes males metabolism metabolites mg/kg mice Michigan microsomal mitogen monkeys observed PBB levels PCB concentration PCB residues PCDFs pesticide Pharmacol phenobarbital plasma polybrominated biphenyls polychlorinated biphenyls population porphyrin protein rats reported response samples sediment serum PBB significant significantly skin species spleen TABLE TCDD TCDF thymus tissue toxicity Toxicol tumor vinyl chloride vitro Wisconsin workers Yusho µg/kg